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KMID : 0358420090520080877
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Korean Journal of Obstetrics and Gynecology
2009 Volume.52 No. 8 p.877 ~ p.882
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A case of primary amelanotic melanoma of the vagina
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Park Mi-Hwa
Park Ji-Kwon
Paik Won-Young
Lee Jong-Hak
Han Yu-Jung
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Abstract
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Primary malignant melanoma of the vagina is extremely rare, accounting for 3% of all primary malignant tumor of the vagina and 0.3~1% of all malignant melanomas in the female. The amelanotic melanoma of the vagina showing no melanin granules on histological examination is exceedingly rare, accounting for only about 10% of all melanoma of the vagina. The amelanotic melanoma of the vagina is often difficult to differentiate from non-epithelial malignant tumor because of the minimal number of melanin granules. We describe a case of primary amelanotic melanoma of the vagina, which was initially suspected to be a non-epithelial malignant tumor, especially malignant peripheral nerve sheath tumor (MPNST), but was correctly diagnosed by HMB-45 antibody and S-100 protein immunohistochemical staining. So we present this case with a brief review of literature.
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KEYWORD
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Amelanotic melanoma, Vagina, Immunohistochemistry
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